Acute Effects of MCT Formulations on Beta-Hydroxybutyrate Response, Lipid Profile, and Glucose Levels in Healthy Adults

Recruiting now · Not applicable

Conditions studied: Ketone Body, Lipid Metabolism, Glucose Response

In brief

The goal of this clinical trial is to evaluate the effects of medium-chain triglycerides (MCTs), delivered in different formulations, on beta-hydroxybutyrate response (as a marker of ketone body production), lipid metabolism, and glucose responses in healthy adults. The main questions it aims to answer are: Do MCTs influence beta-hydroxybutyrate responses, lipid metabolism, and glucose responses differently compared to long-chain triglycerides (LCTs)? Do different types of MCTs (natural sources containing C8 to C12 versus synthetic formulations containing only C8 and C10) lead to different beta-hydroxybutyrate, lipid, and glucose responses? Does the form in which MCTs are consumed (e.g., powders or incorporated into foods) influence beta-hydroxybutyrate production, lipid metabolism, and glucose responses? Researchers will compare five different lipid formulations to evaluate their effects on postprandial beta-hydroxybutyrate concentrations, blood lipid levels, and glucose. Participants will: Consume five different test products on separate study visits. Provide blood samples for up to five hours after each intake for metabolic measurements.

Key facts

Study ID

NCT07718048

Run by

University of Milan

People needed

12

Starts

2026-01-13

Expected to finish

2026-10-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult participants
• Age between 18 and 40 years
• Ability to understand the study procedures and provide informed consent

You may not qualify if…

• Alterations in glucose or lipid metabolism
• Diseases requiring the use of medications that affect glucose or lipid metabolism
• Reported or diagnosed malabsorption conditions
• Pregnancy or breastfeeding

Where it is running

• International Center for the Assessment of Nutritional Status and the development of Dietary Intervention Strategies (ICANS-DIS), Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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