The C-reactive Protein (CRP) Point of Care Testing (POCT) Implementation to Adult Patients Presenting With Symptoms of the Acute Respiratory Tract Infection (ARTI) in Eight Primary Health Care (PHC) in Jakarta.

Recruiting now · Not applicable

Conditions studied: Adults, Acute Respiratory Tract Infection, Antibiotic Prescriptions

In brief

Antimicrobial resistance (AMR) has emerged as one of the most pressing global health challenges of the 21st century, particularly Indonesia is projected to be among the five nations globally with the highest percentage increase in antimicrobial consumption by 2030. Primary care settings represent the most critical implementation point for addressing inappropriate antibiotic use. ARTI constitutes the most common indication for antibiotic prescribing in primary care, yet much of this prescribing is inappropriate. The high frequency of inappropriate antibiotic prescribing for ARTI is particularly problematic because most of these infections are viral in nature and resolve spontaneously without antibiotic treatment. Studies across the Asia-Pacific region, including Indonesia, have documented antibiotic prescribing rates for upper respiratory tract infections ranging from 47% to 85%, indicating substantial overuse. C-reactive protein (CRP) point-of-care test (POCT) has emerged as a promising, evidence-based implementation to reduce inappropriate antibiotic prescribing for acute respiratory infections in a systematic review of studies conducted primarily in primary care settings of high- and middle-income countries. However, the efficacy and safety of CRP POCT implementation have not been evaluated in Indonesian primary care settings, where healthcare infrastructure, patient populations, test acceptability, and prescribing practices may differ significantly from countries where studies have been conducted. This research will fill a critical evidence gap by providing the first rigorous evaluation of CRP POCT in the Indonesian context. The findings will directly inform Indonesia's National Strategy for AMR Standard and provide evidence-based guidance for scaling antimicrobial stewardship implementations across Indonesian PHC sites. Reducing inappropriate antibiotic prescribing by implementing CRP will contribute to reduce the development of antimicrobial resistance, unnecessary adverse effects, and healthcare costs.

Key facts

Study ID: NCT07717372
Run by: Oxford University Clinical Research Unit Indonesia
People needed: 2544
Starts: 2026-04-06
Expected to finish: 2026-10-01
Last updated by the study team: 2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Adults aged ≥18 years.
Presenting to the PHC site for the first consultation of the current episode of Acute-Respiratory Tract Infections (ARTI).
Reporting at least one of the following symptoms or clinical signs within the past 5 days: cough, rhinitis (e.g., sneezing, nasal congestion, or runny nose), pharyngitis (e.g., sore throat), shortness of breath, wheezing, chest pain, abnormal lung sounds on auscultation.

You may not qualify if…

Presenting with severe illness requiring referral to a higher-level healthcare facility (e.g., hospital).
Having known immunosuppression or chronic conditions, including but not limited to: HIV infection; chronic liver disease; history of malignancy; long-term use of systemic corticosteroids or other immunosuppressive therapies, as assessed by the healthcare worker or study team.
Having taken antibiotics prior to the visit to the primary health center.

Where it is running

Koja Public Health Center — Jakarta, Indonesia (enrolling)
Cengkareng Public Health Center — Jakarta, Indonesia (enrolling)
Pulo Gadung Public Health Center — Jakarta, Indonesia (enrolling)
Jatinegara Public Health Center — Jakarta, Indonesia (enrolling)
Duren Sawit Public Health Center — Jakarta, Indonesia (enrolling)
Cakung Public Health Center — Jakarta, Indonesia (enrolling)
Cilincing Public Health Center — Jakarta, Indonesia (enrolling)
Kebayoran Lama Public Health Center — Jakarta, Indonesia

Full record on ClinicalTrials.gov

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