Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance

Recruiting now

Conditions studied: Haemodiafiltration, Haemodialysis, Patient Reported Outcome Measurements, Nutrition, Malnutrition (Calorie), Fluid Balance Outcomes

In brief

The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\>23Litres (L)) vs Low (\<23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol/L) on overhydration volume in patients on HD and HDF.

Key facts

Study ID

NCT07717255

Run by

East and North Hertfordshire NHS Trust

People needed

300

Starts

2025-01-09

Expected to finish

2030-11-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or above.
• Ability to give informed consent.
• End stage kidney disease (ESKD) treated by haemodialysis for at least 3 months.
• Prognosis > 6 months as assessed by principal investigator (PI)

Where it is running

• Lister Hospital, East and North Hertfordshire NHS Trust — Stevenage, Hertfordshire, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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