ASPB-PIPB Combination in Cardiac Surgery

Starting soon · Not applicable

Conditions studied: Postoperative Pain, Cardiac Surgery, Cardiopulmonary Bypass, Median Sternotomy

In brief

Cardiopulmonary bypass surgery is associated with significant postoperative pain, which may adversely affect respiratory function, delay mobilization, prolong hospital stay, and increase postoperative complications. Within Enhanced Recovery After Surgery (ERAS) protocols, multimodal analgesia and opioid-sparing strategies have become essential components of perioperative care. Ultrasound-guided fascial plane blocks, including the anterior serratus plane block (ASPB) and pectoral-intercostal plane block (PIPB), have emerged as effective and safe regional anesthesia techniques for cardiac surgery, targeting different sensory innervation of the thoracic wall. However, evidence regarding the combined use of these two blocks remains limited. This study aimed to evaluate whether the combination of ASPB and PIPB improves intraoperative and postoperative analgesia, reduces opioid consumption, and enhances postoperative recovery and ERAS outcomes compared with standard analgesic management in patients undergoing cardiopulmonary bypass surgery.

Key facts

Study ID

NCT07716943

Run by

Sisli Hamidiye Etfal Training and Research Hospital

People needed

60

Starts

2026-07-01

Expected to finish

2027-06-30

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing open heart surgery via median sternotomy by the Cardiovascular Surgery Clinic
• Patients over 18 years of age
• ASA II-III patients

You may not qualify if…

• - Patients undergoing emergency or recurrent surgery
• Patients with left ventricular ejection fraction < 30
• Patients who died per-operatively
• Patients who do not provide informed consent
• Presence of chronic pain
• Presence of allergy to local anesthetics
• Presence of infection in the area where the block will be performed
• Coagulopathy
• Pre-existing neurological deficit
• Mental retardation
• Anatomical deformity

Where it is running

• Sisli etfal research and training hospital — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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