PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients

Starting soon · Not applicable

Conditions studied: GERD

In brief

This is a prospective, within-subject controlled study involving simultaneous dual placement of wireless Bravo pH probes in each participant. Patients will receive pH testing when symptomatic for gastroesophageal reflux disease (GERD) to confirm diagnosis as part of standard of care. Each test is 96 hours with a symptom diary, GERD-HRQL, and RSI collected, which is also standard of care for patients presenting with GERD symptoms.

Key facts

Study ID

NCT07716592

Run by

University of Chicago

People needed

80

Starts

2026-08-01

Expected to finish

2028-12-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-90
• Typical GERD symptoms (heartburn, regurgitation, chest discomfort)
• No prior foregut surgery
• Ability to undergo endoscopy with sedation and consent

You may not qualify if…

• Known motility disorders (e.g., achalasia)
• Barrett's esophagus >3 cm
• Pregnancy
• Chronic opioid use
• Inability to tolerate endoscopy or EndoFLIP
• Presence of large type III or IV paraesophageal hernia
• Previous esophageal or gastric surgery, including previous hiatal hernia repair

Where it is running

• The University o Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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