Homeless Overdose Prevention- Expansion

Starting soon · Not applicable

Conditions studied: Homelessness, Opioid Education and Naloxone Distribution (OEND), Substance Use Disorder

In brief

Homeless Overdose Prevention - Expansion (HOPE), tests implementation of overdose education and naloxone distribution (OEND), a program that targets homeless experienced Veterans at risk for overdose, including Veterans in community-based supportive housing. HOPE sites will receive a playbook that offers step-by-step instructions, tools, templates, and checklists tailorable to site needs; sites will also receive performance feedback about their performance relative to a standard or benchmark.

Key facts

Study ID

NCT07716202

Run by

VA Office of Research and Development

People needed

1200

Starts

2026-08-31

Expected to finish

2030-09-30

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans enrolled in HUD-VASH at risk for opioid overdose (based on existing HOPE algorithms aligned with Pharmacy Benefit Manager data definitions), drawing from VA administrative data.

You may not qualify if…

• Not flagged by existing HOPE algorithms
• Not currently enrolled in HUD-VASH
• Is not a patient at a participating site of the implementation trial

Where it is running

• VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States

Full record on ClinicalTrials.gov

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