ENDoscopic Assessment in Acute PANcreatitis Study (ENDOPAN Study)

Starting soon

Conditions studied: Acute Pancreatitis (AP)

In brief

This is a prospective observational cohort study designed to evaluate early upper gastrointestinal endoscopic findings in adult patients hospitalized with acute pancreatitis. The study aims to determine whether gastric and duodenal mucosal abnormalities detected during early hospitalization are associated with the severity and clinical course of acute pancreatitis. Adult patients diagnosed with acute pancreatitis according to the revised Atlanta criteria will be enrolled after providing informed consent. Upper gastrointestinal endoscopy will be performed within 24-48 hours from hospital admission. In patients with moderately severe or severe acute pancreatitis, a follow-up endoscopy may be performed before discharge. Clinical, laboratory, imaging, microbiological, and endoscopic data will be collected prospectively during the index hospitalization. The primary objective is to assess the association between early endoscopic mucosal abnormalities and acute pancreatitis severity according to the revised Atlanta classification. Secondary objectives include evaluation of the relationship between endoscopic findings and organ failure, local or systemic complications, inflammatory markers, nutritional tolerance, length of hospital stay, need for invasive interventions, and in-hospital mortality. The study has received a positive opinion from the Bioethics Committee of Jan Kochanowski University in Kielce, Collegium Medicum, resolution no. 27/2026 dated May 20, 2026.

Key facts

Study ID

NCT07714850

Run by

Jan Kochanowski University

People needed

200

Starts

2026-09-01

Expected to finish

2029-09-30

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older.
• Diagnosis of acute pancreatitis according to the revised Atlanta criteria, defined by the presence of at least two of the following three features:
• typical abdominal pain consistent with acute pancreatitis; serum amylase and/or lipase activity at least three times the upper limit of normal; imaging findings consistent with acute pancreatitis.
• Hospital admission due to acute pancreatitis to the study center.
• Admission during the early phase of acute pancreatitis, allowing planned upper gastrointestinal endoscopy within 24-48 hours from hospital admission.
• Ability to undergo diagnostic upper gastrointestinal endoscopy according to the investigator's and treating physician's assessment.
• Ability to provide written informed consent before enrollment and before any study-specific procedure.

You may not qualify if…

• Age below 18 years.
• Lack of written informed consent.
• Inability to provide informed consent before enrollment.
• Clinical condition precluding safe diagnostic upper gastrointestinal endoscopy, including hemodynamic instability, severe respiratory failure, or other unstable life-threatening condition.
• Need for emergency therapeutic upper gastrointestinal endoscopy before planned study endoscopy, for example due to active upper gastrointestinal bleeding.
• Known or suspected gastrointestinal perforation.
• Previous gastric or duodenal surgery significantly altering upper gastrointestinal anatomy and preventing reliable assessment of gastric or duodenal mucosa.
• Known advanced upper gastrointestinal malignancy affecting the stomach or duodenum.
• Pregnancy.
• Contraindication to upper gastrointestinal endoscopy or sedation according to the treating physician's or investigator's assessment.
• Any condition that, in the investigator's opinion, would make participation unsafe or would prevent completion of study procedures.

Full record on ClinicalTrials.gov

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