Effectiveness of Video-Based Movement Analysis-Guided Personalized Rehabilitation in Patients With CIPN: A Multicenter Trial

Enrolling by invitation · Not applicable

Conditions studied: Chemotherapy-induced Peripheral Neuropathy (CIPN)

In brief

This study aims to quantify motor control abnormalities using video-based movement analysis in patients with chemotherapy-induced peripheral neuropathy (CIPN) and to evaluate the effectiveness of an analysis-guided personalized rehabilitation intervention. The study enrolls adult patients diagnosed with breast cancer, colorectal cancer, or gynecological cancer. This is a randomized crossover trial where participants have an equal (50%) chance of being assigned to either Group A or Group B. The total participation period for each participant is approximately 8 weeks, which includes outcome assessments at baseline, week 4, and week 8. The study consists of two periods: Phase 1 (First 4 weeks): Group A participates in the 'ReMAP' rehabilitation exercise program, while Group B receives usual care. Phase 2 (Next 4 weeks): Group A switches to usual care, while Group B participates in the 'ReMAP' rehabilitation exercise program.

Key facts

Study ID

NCT07714278

Run by

Seoul National University Bundang Hospital

People needed

150

Starts

2026-06-30

Expected to finish

2028-05-31

Last updated by the study team

2026-07-20

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 19 years or older.
• Diagnosed with breast cancer, colorectal cancer, or gynecological cancer, and currently receiving chemotherapy or under follow-up observation after completing treatment.
• History of treatment with neurotoxic chemotherapeutic agents (e.g., taxane, platinum, etc.) or experiencing related symptoms.
• Symptoms or risk of chemotherapy-induced peripheral neuropathy (CIPN) (NCI-CTCAE Grade >= 1).
• Able to walk independently (with or without assistive devices).
• Able to understand the study purpose and procedures and voluntarily provide written informed consent.

You may not qualify if…

• Peripheral neuropathy clearly attributable to causes other than CIPN, such as diabetic neuropathy.
• Severe central nervous system disorders (e.g., stroke, Parkinson's disease, etc.) or severe musculoskeletal disorders that make functional assessment or exercise performance difficult.
• Severe cognitive impairment that interferes with study participation or the ability to follow instructions.
• Recent significant injury due to a fall, or cases where exercise performance is deemed medically unsafe.
• Recurrent or progressive cancer with an unstable general systemic condition.
• Any other condition or clinical reason that, in the opinion of the investigator, makes participation in the study inappropriate.

Where it is running

• Seoul National University Bundang Hospital — Seongnam-si, Gyeonggi-do, South Korea

Full record on ClinicalTrials.gov

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