Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance

Starting soon · Not applicable

Conditions studied: Renal Cell Carcinoma (RCC)

In brief

This clinical trial compares two different weight-loss programs, daily continuous calorie energy reduction (CER) versus (vs.) 5:2 intermittent fasting (IF), in preventing progression of kidney (renal) cancer among patients with one or more small renal masses (SRM) undergoing active surveillance (AS). Kidney cancer patients tend to have changes in metabolism that may increase body weight, but weight-loss strategies that work for best for these patients are unknown. The CER program requires a set daily limit for calories. The IF program requires fasting for 2 days a week and normal eating for the remaining 5 days. Both will include self-monitoring with interventionist feedback. This trial may help researchers determine whether the IF program works better than the CER program in improving weight loss, physical health, and/or reducing the risk of kidney cancer progression among patients with small renal masses undergoing AS

Key facts

Study ID

NCT07714018

Run by

Roswell Park Cancer Institute

People needed

20

Starts

2026-09-01

Expected to finish

2028-09-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English speaking
• SRM patient with biopsy-confirmed RCC who are initiating or already on AS for less than 5 years
• Age 18 years or older
• Body mass index (BMI) ≥ 25 kg/m\^2
• No medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
• No current medication that might affect weight loss
• Not pregnant or lactating
• No more than 5% body weight loss in the past 3 months
• No bariatric surgery in the last 10 years

You may not qualify if…

• Non-English speaking
• Less than 18 years old
• BMI < 25 kg/m\^2
• Medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
• Current medication that might affect weight loss
• Pregnant or lactating
• More than 105% body weight loss in the past 6 months
• Bariatric surgery in the last 10 years
• Medical conditions that might contraindicate short-term fasting periods
• Unwilling or unable to follow protocol requirements
• Received an investigational agent within 30 days prior to enrollment

Where it is running

• Roswell Park Comprehensive Cancer Center — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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