Understanding the Paradoxical Rise in Blood Glucose in the Context of a Low-carbohydrate Diet
Completed · Not applicable
Conditions studied: Elevated Blood Glucose, Low-carbohydrate Diet
In brief
The purpose of this project was to elucidate the phenomenon of elevated blood glucose in the context of dietary carbohydrate restriction. Accordingly, we sought to quantify glucagon, and related hormones, between individuals that are adhering to a low-carbohydrate diet that manifests with normal vs. elevated glucose. Moreover, we sought to test the dynamic effect of macronutrients on these same outcomes. Each participant completed 3 testing periods that included the consumption of a glucose drink, protein drink, or fat (olive oil) drink in a random order and separated by at least 2 days. Each drink was matched for volume and total calories and bloodwork was taken every 30 minutes to assess the outcomes of interest.
Key facts
- Study ID
- NCT07713316
- Run by
- Brigham Young University
- People needed
- 24
- Starts
- 2021-05-15
- Expected to finish
- 2022-12-17
- Last updated by the study team
- 2026-07-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- weight stable (± 3% body weight) for the past 3 months
- adhering to a low-carbohydrate (50g carbohydrates or less per day) diet at least 2 weeks prior to and during the duration of the one-month study
You may not qualify if…
- unwilling to provide written consent
- diagnosed with chronic disease(s) including cardiac disease, cancer, or liver disease,
- pregnant or lactating,
- taking medications that alter metabolism,
- allergies to latex, cow's milk/milk products, olives, chlorhexidine, or dextrose,
- have had more than 5 x-rays in the past year.
Where it is running
- Brigham Young University — Provo, Utah, United States
Full record on ClinicalTrials.gov
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