OCT-PRO Model vs. Clinicians: Cataract Surgery Outcome Prediction

Starting soon · Not applicable

Conditions studied: Cataract

In brief

Cataract is the leading cause of blindness worldwide, yet 5-20% of patients fail to achieve satisfactory visual recovery after surgery. Current methods for predicting postoperative visual acuity lack accuracy, particularly in patients with co-morbid fundus diseases. The OCT-PRO model, developed by our team, uses artificial intelligence (AI) to integrate optical coherence tomography (OCT) images and clinical data to forecast surgical outcomes. This multi-center, randomized, single-blind trial aims to compare the predictive accuracy of OCT-PRO-assisted predictions versus standard clinician predictions. A total of 534 participants will be randomized 1:1 to either the experimental group (OCT-PRO-assisted prediction) or the control group (routine care). The primary outcome is the mean absolute error (MAE) between predicted and actual postoperative best-corrected visual acuity (BCVA). Secondary outcomes include patient satisfaction, informed decision-making scores, and clinician acceptance of the AI tool. This study will provide high-level evidence on the clinical utility of AI in optimizing cataract surgical decision-making and patient communication.

Key facts

Study ID

NCT07713069

Run by

Zhongshan Ophthalmic Center, Sun Yat-sen University

People needed

534

Starts

2026-07-20

Expected to finish

2026-12-31

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years scheduled to undergo phacoemulsification with intraocular lens (Phaco+IOL) implantation.
• Outpatient diagnosis of senile, complicated, or metabolic cataract.
• For bilateral cataracts, the eye with more advanced disease will be included.

You may not qualify if…

• History of amblyopia or neuro-ophthalmic disease in the operative eye.
• Poor-quality OCT images precluding clear visualization of fundus structures.
• Previous intraocular surgery in the operative eye.
• Hearing or intellectual impairment preventing adequate cooperation.

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.