Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

Starting soon · Not applicable

Conditions studied: Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer

In brief

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce the risk of dying from lung cancer, but many people who are eligible for screening do not receive it. The purpose of the Empower LCS/Call+ study is to evaluate new strategies to improve lung cancer screening among adults who are eligible for screening based on current U.S. Preventive Services Task Force (USPSTF) guidelines. This pilot randomized controlled trial will enroll approximately 80 participants from UC Irvine Health and Emory Healthcare. Participants will be randomly assigned to receive either enhanced usual care or the Empower LCS/Call+ intervention. The intervention includes educational materials, reminders for patients and primary care providers, and information about financial and community resources when appropriate. Participants who do not complete lung cancer screening after the initial intervention may receive additional telephone-based navigation through the Call+ program to help identify and address barriers to screening and help with scheduling. Participants will complete a baseline survey and follow-up surveys at 4 and 8 months, and researchers will review electronic health record information to determine whether lung cancer screening was discussed, ordered, and completed. Some participants will also be invited to complete a one-time interview about their experiences with the study. The results of this study will help determine the feasibility, acceptability, and preliminary effectiveness of the Empower LCS/Call+ intervention and will inform future efforts to improve equitable access to lung cancer screening.

Key facts

Study ID

NCT07711691

Run by

University of California, Irvine

People needed

80

Starts

2026-09-01

Expected to finish

2028-12-01

Last updated by the study team

2026-07-22

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must meet current USPSTF eligibility criteria for lung cancer screening (Current criteria: age 50-80 years old with a 20 pack-year smoking history, who currently smoke or have quit within the last 15 years)
• Must have an electronic health record-assigned primary care provider within University of California Irvine Health or Emory Healthcare
• Must have recent engagement with respective health system (i.e., office or emergency department (ED) visit, hospitalization with discharged home in the last 12 months, or a scheduled office visit in the next 3 months).
• Must speak English or Spanish
• Able and willing to provide informed consent

You may not qualify if…

• Meet the eligibility upper age limit during initial 4-month participation.
• Have a prior history of lung cancer.
• Have a new diagnosis of other cancers in the 12 months
• Have a chest CT or LDCT in the last 12 months
• Have ICD-10 code of Alzheimer's disease in EHR

Where it is running

• UCI Health - Costa Mesa — Costa Mesa, California, United States
• CHAO Family Comprehensive Cancer Center- Irvine — Irvine, California, United States
• UCI Health Gottschalk Medical Plaza — Irvine, California, United States
• UCI Health - Laguna Hills — Laguna Hills, California, United States
• UCI Health - Newport Beach MacArthur — Newport Beach, California, United States
• Primary Care & Internal Medicine Services — Orange, California, United States
• UCI Chao Family Comprehensive Cancer Center — Orange, California, United States
• UCI Health SeniorHealth Center -Pavillion 4 — Orange, California, United States
• UCI Medical Center, Pavilion 3 — Orange, California, United States
• UCI Health Family Health Center - Santa Ana — Santa Ana, California, United States
• UCI Health - Tustin — Tustin, California, United States
• UCI Health - Yorba Linda — Yorba Linda, California, United States
• Emory at Avalon - Primary Care — Alpharetta, Georgia, United States
• Emory Clinic at Old Fourth Ward — Atlanta, Georgia, United States
• Emory Clinic at Midtown — Atlanta, Georgia, United States
• Emory at Peachtree Hills - Primary Care — Atlanta, Georgia, United States
• Emory Clinic at 1365 Clifton Road - Primary Care — Atlanta, Georgia, United States
• Emory Clinic at 1525 Clifton Road - Primary Care — Atlanta, Georgia, United States
• Emory at Toco Hills - Primary Care — Atlanta, Georgia, United States
• Emory Gastroenterology — Atlanta, Georgia, United States
• Emory at Northlake - Primary Care — Atlanta, Georgia, United States
• Emory at Buford - Primary Care — Buford, Georgia, United States
• Emory at Decatur - Primary Care (Irvin Court) — Decatur, Georgia, United States
• Emory at Decatur - Primary Care (Scott Boulevard) — Decatur, Georgia, United States
• UCI Health Family Health Center - Anaheim — Anaheim, California, United States

Full record on ClinicalTrials.gov

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