Simple Non-cultured Endothelial Cell Therapy for Corneal Endothelial Dysfunction

Recruiting now · Phase 1

Conditions studied: Bullous Keratopathy, Corneal Endothelial Dystrophy

In brief

Assessment of safety and efficacy of cell injection therapy generated using non-cultured human corneal endothelial cells in treating corneal endothelial dysfunction

Key facts

Study ID

NCT07711561

Run by

Singapore Eye Research Institute

People needed

20

Starts

2026-06-22

Expected to finish

2029-07-01

Last updated by the study team

2026-07-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have mild to moderate corneal endothelial decompensation or bullous keratopathy, but with minimal corneal stromal scarring resulting from irreversible post-surgical corneal decompensation, specifically, all forms of pseudophakic or aphakic bullous keratopathy.

You may not qualify if…

• Severe forms or late-stage presentation of corneal decompensation with severe corneal stromal scarring and or scarring to the DM, unsuitable for SNEC-I.
• Patients with complex anterior segment complications precluding a successful SNEC-I procedure
• Patients who have other forms of endothelial dystrophy, traumatic corneal decompensation, or post-inflammatory corneal decompensation
• Post-laser iridotomy or glaucoma related corneal decompensation
• Patients not keen to participate in the clinical trial
• Patients who are below 21 years of age or above 80 years of age
• Patients who are pregnant
• Patients who are cognitively impaired
• Patients who are prisoners
• Patients with antibiotics/antimycotics allergies

Where it is running

• L V Prasad Eye Institute — Hyderabad, Telangana, India (enrolling)

Full record on ClinicalTrials.gov

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