Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

Starting soon · Not applicable

Conditions studied: Obesity & Overweight, Weight Loss Maintenance

In brief

So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy. This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.

Key facts

Study ID

NCT07711548

Run by

Knut Mai

People needed

292

Starts

2027-03-01

Expected to finish

2030-04-01

Last updated by the study team

2026-07-20

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• BMI ≥ 30 kg/m² OR ≥ 27 kg/m² with concomitant cardiometabolic risk factors (metabolic syndrome, elevated blood pressure, dyslipidemia or impaired glucose metabolism (but not type 2 diabetes)

You may not qualify if…

• BMI ≥ 45 kg/m²
• intake of glucose lowering drugs
• presence of incretin-based treatment
• acute severe CVD
• uncontrolled hypertension
• severe hepatic or renal diseases
• severe food allergy or malabsorption disease
• active cancer
• condition after bariatric surgery
• history of eating disorder
• concurrent pregnancy and breastfeeding

Full record on ClinicalTrials.gov

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