A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers

Recruiting now · Not applicable

Conditions studied: Smoking, Tobacco

In brief

The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP). The primary study objective is to evaluate the impact of access to HTP Device 1 or HTP Device 2 and a single stick variant on the rate of final 7-day abstinence from smoking cigarettes among U.S. adult smokers at the end of a 3-month study period.

Key facts

Study ID

NCT07710820

Run by

RAI Services Company

People needed

1060

Starts

2026-07-01

Expected to finish

2026-12-01

Last updated by the study team

2026-07-17

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to read, understand, and are willing to sign an Informed Consent Form (ICF) and complete questionnaires written in English.
• Generally healthy male or female, between 21 and 65 years of age, inclusive, at the time of consent, verified with government-issued identification.
• All female (assigned at birth) candidate participants who agree to take the pregnancy test on site and receive a negative result, and who affirm at the SEV that they are not pregnant or intending to become pregnant. Note: Participants who identify as "intersex" or "unknown" during screening, will be required to take a pregnancy test if they wish to take one.
• Currently smoke at least five combustible cigarettes on smoking days in the past 30 days.
• Smoke combustible cigarettes on 15 or more of the past 30 days.
• Smoked at least 100 factory-made filtered menthol and/or non-menthol combustible cigarettes in their lifetime prior to the Site Enrollment Visit.
• Must indicate a neutral/positive intention to use at least one stick variant at the Site Enrollment Visit.
• Own a smartphone (iOS or Android) with internet access to download a study application to access surveys and the capability to receive notifications.
• Agree to participate in the study and to abide by the study restrictions and requirements, as described in the ICF.
• Must try all four stick variants during the 1-week product trial period.
• Must indicate a neutral/positive intention to use at least one stick variant following the product trial period.

You may not qualify if…

• Female participants who are pregnant or breastfeeding or planning to become pregnant or start breastfeeding within the next 6 months based on self-report.
• Male participants who self-report they are not willing to use a barrier method of contraception (e.g., a condom with spermicide) or refrain from donating sperm from the time of the signing of the ICF until the end of the study, unless they have undergone a vasectomy or are abstinent from heterosexual intercourse, or their female partner was not able to bear children.
• Female participants who self-report not using adequate methods to prevent pregnancy.
• Persons with pacemakers or other embedded electronic medical devices fitted.
• Participants who self-report having an unstable heart condition, severe hypertension, or diabetes.
• Individuals who respond with 'Poor' or 'Don't know' to general physical or mental health.
• Participants who have used electronic nicotine delivery system (ENDS), nicotine pouches, HTP or smokeless tobacco (i.e., chewing tobacco, snus, or snuff) products, other combustible tobacco/nicotine products, and other oral nicotine products (tablets, gums, and lozenges) on 5 or more days in the past 30 days.
• Participants who have used a nicotine replacement therapy (NRT) product or a prescription drug to help stop smoking (e.g., varenicline, bupropion) in the past 30 days.
• Employee of a company that manufactures tobacco or HTPs.
• Persons who are personally, have household members, or have close family or friends in litigation with a company that manufactures tobacco or HTPs.
• Have taken part in a tobacco/nicotine research study in the past 30 days.

Where it is running

• Opinions Brandon — Brandon, Florida, United States (enrolling)
• Opinions Coral Springs — Coral Springs, Florida, United States (enrolling)
• Opinions Chicago — Aurora, Illinois, United States (enrolling)
• Opinions Chicago — Gurnee, Illinois, United States (enrolling)
• Opinions Las Vegas — Las Vegas, Nevada, United States (enrolling)
• Opinions Las Vegas — Las Vegas, Nevada, United States (enrolling)
• Opinions Fort Worth — Fort Worth, Texas, United States (enrolling)
• Opinions Houston — Houston, Texas, United States (enrolling)
• Opinions Dallas — Hurst, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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