Exercise to Improve Outcomes in Pancreatic Cancer

Recruiting now · Not applicable

Conditions studied: Pancreas Adenocarcinoma (MSI-H), Deconditioning

In brief

Pancreatic cancer surgery (Whipple's procedure) is a major operation that can lead to reduced physical fitness, delayed recovery, and difficulty starting chemotherapy after surgery. Exercise before and after surgery may help improve recovery, but it is not known whether a personalised exercise programme delivered throughout the surgical pathway is practical or acceptable for patients. The Exercise to Improve Outcomes in Pancreatic Cancer (ExO-PanC) study is a single-arm feasibility study that will recruit adults with suspected pancreatic ductal adenocarcinoma who are scheduled to undergo Whipple's procedure. Participants will receive an individualised exercise programme before surgery, during their hospital stay, and after discharge until the start of adjuvant chemotherapy. The programme will include aerobic exercise and resistance training prescribed according to each participant's fitness level. The primary objective is to determine whether this exercise programme is feasible by assessing recruitment, participant adherence, compliance with the prescribed exercise programme, and retention. Secondary exploratory objectives include evaluating surgical complications, initiation of adjuvant chemotherapy, physical fitness, quality of life, nutritional status, and blood, stool, and tumour biomarkers associated with clinical outcomes. Findings from this feasibility study will inform the design of a future multicentre randomised controlled trial evaluating the effectiveness of the ExO-PanC programme.

Key facts

Study ID

NCT07710495

Run by

University of Surrey

People needed

60

Starts

2026-07-06

Expected to finish

2030-06-01

Last updated by the study team

2026-07-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older.
• Planned to undergo upfront pancreatoduodenectomy (Whipple's procedure) for a suspected malignant periampullary mass.
• Able and willing to provide written informed consent.

You may not qualify if…

• <18 years age
• Cardiopulmonary exercise test (CPET) contraindications
• Physical inability to perform CPET or undertake the program.
• Lacking the capacity to consent
• Unable to understand instructions in English
• Not scheduled for surgery
• A new diagnosis of Type 1 or Type 3c diabetes requiring management with insulin prescription will be excluded from the study.

Where it is running

• University of Surrey — Guildford, Surrey, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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