Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
Starting soon · Not applicable
Conditions studied: Prophylactic, Anticoagulation
In brief
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026 to Mars 2027. Aim of the study will be: 1. Compare the incidence of clinically significant catheter-related complications (catheter occlusion requiring intervention or catheter-related thrombosis) within 14 days after CVL insertion between children receiving prophylactic anticoagulation and those receiving standard care. 2. Compare time-to- first catheter occlusion. 3. Compare rate of catheter-related bloodstream infection (CLABSI) within 30 days. 4. Compare number of catheter manipulations and unplanned catheter removals. 5. Compare major and minor bleeding events. 6. Assess catheter dwell time and need for thrombolysis or therapeutic anticoagulation.
Key facts
- Study ID
- NCT07710482
- Run by
- Menoufia University
- People needed
- 40
- Starts
- 2026-08-01
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2026-07-20
Who can join
Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All Children requiring a newly placed central venous line (peripherally inserted central catheter [PICC], or non-tunneled central venous catheter) for clinical care.
You may not qualify if…
- Known major congenital bleeding diathesis or platelet count <50,000/µL at time of insertion.
- Already on therapeutic anticoagulation for another indication.
- Known heparin allergy or history of heparin-induced thrombocytopenia.
- Use of dialysis catheters (study focuses on standard CVCs/PICCs).
Where it is running
- Menoufia university hospital, Pediatric intensive care unit — Shibīn al Kawm, Menoufia Governorate, Egypt
Full record on ClinicalTrials.gov
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