Effectiveness of the Personalized Responses & Integrated Systems for Metabolism (PRISM) on Improving Insulin Resistance Among Adults With Metabolic Syndrome: A Pilot Study (PRISM-I)

Starting soon · Not applicable

Conditions studied: Metabolic Syndrome (MetS)

In brief

The primary objective of the Personalized Responses \& Integrated Systems for Metabolism (PRISM-I) pilot study is to assess the feasibility of conducting a definitive randomized controlled trial evaluating precision lifestyle interventions for improving insulin resistance in adults with metabolic syndrome.

Key facts

Study ID

NCT07710274

Run by

National University Health System, Singapore

People needed

200

Starts

2026-07-01

Expected to finish

2027-07-01

Last updated by the study team

2026-07-17

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants will be included for if they are:
• (1) adults aged 21-70 years old;
• (2) willing and able to comply with using a CGM, smart ring, food logging app
• (3) able to provide written informed consent;
• (4) English-speaking and literate;
• (5) meet the inclusion criteria for metabolic syndrome and insulin resistance.
• The criteria for insulin resistance is HOMA-IR ≥ 2.5.
• The criteria for metabolic syndrome is to have high waist circumference (≥ 80cm for females and ≥ 90cm for males); and any two of the four below:
• (1) raised triglycerides: 1.7 mmol/L or on treatment;
• (2) reduced HDL cholesterol: < 1.0 mmol/L (40 mg/dL) in men, < 1.3 mmol/L (50 mg/dL) in women, or on treatment;
• (3) high blood pressure: 130/85 mmHg or on treatment; or
• (4) raised fasting glucose: 5.6 mmol/L (100 mg/dL) or previously diagnosed with T2DM

You may not qualify if…

• Participants will be excluded from both phases if they are:
• (1) on insulin therapy;
• (2) are pregnant or lactating;
• (3) have a medical condition or are on a treatment that may interfere with study participation or metabolic assessments, as determined by the study investigators;
• (4) currently participating in other lifestyle modification programs.

Where it is running

• National University of Singapore — Singapore, Singapore

Full record on ClinicalTrials.gov

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