A Multicenter Clinical Study on Protein Absorption Efficiency in Patients With Pancreatic Exocrine Insufficiency in the ICU

Starting soon · Phase 4

Conditions studied: High-risk Patients With Pancreatic Exocrine Insufficiency, Enteral Nutrition Feeding

In brief

The goal of this clinical trial is to systematically evaluate whether peptide-type enteral nutrition (EN) formulations improve protein uptake efficiency in high-risk groups at ICU PEI, using targeted amino acid metabolomics and gut microbiota co-metabolomics as core quantitative indicators. Researchers will compare protein absorption efficiency of short-chain peptide and complete protein enteral nutrition formulas in high-risk populations for PEI in the ICU Participants will: Enteral nutrition was administered for ICU critically ill patients with high-risk factors for PEI

Key facts

Study ID

NCT07709611

Run by

Shanghai 10th People's Hospital

People needed

250

Starts

2026-07-01

Expected to finish

2027-12-31

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age≥ 18 years old, no gender restriction;
• Meet the criteria for high-risk groups for PEI;
• AGI≤ Class II, hemodynamically stable, meeting EN initiation criteria;
• Estimated duration of enteral nutrition support therapy: ≥7 days;
• The subject or their legally authorized family member must sign the informed consent form

You may not qualify if…

• Patients who have been clearly diagnosed with PEI or chronic persistent PEI;
• Patients who have contraindications to enteral nutrition therapy;
• Patients with severely impaired liver or kidney function;
• Patients who suffer from amino acid metabolism disorders, severe malnutrition, or cachexia;
• Patients who have received pancreatic enzyme replacement therapy or taken any medications that may affect protein absorption within 7 days prior to enrollment;
• Patients for whom the expected length of ICU stay is less than 7 days;
• Pregnant or lactating women, as well as patients with mental illnesses;
• Patients who are allergic to any component of the study medication.

Where it is running

• Shanghai Tongji Hospital — Shanghai, China

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.