Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation Versus Conventional Management in Weaning Window Patients

Recruiting now · Not applicable

Conditions studied: Airway Occlusion Pressure, Pressure Support Ventilation, Conventional Management, Weaning Window Patients

In brief

This study aims to determine whether Airway Occlusion Pressure (P0.1) Guided Pressure Support Ventilation is superior to conventional management for patients in weaning windows.

Key facts

Study ID

NCT07709182

Run by

Tanta University

People needed

80

Starts

2026-02-01

Expected to finish

2028-01-01

Last updated by the study team

2026-07-16

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mechanically ventilated adult patients ≥ 21 years.
• Patients on pressure support ventilation for at least 24 hours and clinically determined to be in the weaning window (transition between assisted ventilation and spontaneous ventilation) with improving respiratory status.
• Hemodynamically stable [mean arterial pressure (MAP) ≥60 mmHg].
• All patients will be required to have light sedation with a Richmond Agitation-Sedation Scale (RASS) score between -1 and 0 to allow reliable assessment of respiratory drive.

You may not qualify if…

• Patients with neuromuscular disorders affecting respiratory drive
• Glasgow Coma Scale (GCS) score below 8
• Cervical spinal cord injury
• Receipt of neuromuscular blockers within the previous 24 hours
• Morbid obesity resulting in unreliable respiratory mechanics
• Pregnancy
• Deep sedation defined as RASS ≤ -2
• Hemodynamic instability requiring escalating vasopressor support.

Where it is running

• Tanta University — Tanta, Al Gharbia, Egypt (enrolling)

Full record on ClinicalTrials.gov

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