Clinical Phenotype and Prevalence of VEXAS Syndrome in Internal Medicine
Starting soon
Conditions studied: Vexas Syndrome
In brief
The FIND-VEXAS project is a multicenter, cross-sectional observational study conducted in Internal Medicine departments in the Friuli Venezia Giulia region of Italy. The study aims to estimate how frequently VEXAS syndrome occurs among adults older than 50 years who are admitted to Internal Medicine units with otherwise unexplained systemic inflammation or hematologic abnormalities, such as fever, elevated inflammatory markers, macrocytic anemia, thrombocytopenia, or other cytopenias. Participants will be assessed using clinical information, physical examination findings, routine laboratory tests, and imaging data. Patients with findings suggestive of VEXAS syndrome will be selected for confirmatory genetic testing of the UBA1 gene using blood or bone marrow samples. In addition to estimating the prevalence of genetically confirmed VEXAS syndrome, the study will describe the clinical manifestations, hematologic abnormalities, inflammatory profile, and organ involvement of patients with suspected or confirmed disease.
Key facts
- Study ID
- NCT07708688
- Run by
- Centre Hospitalier Universitaire Vaudois
- People needed
- 50
- Starts
- 2026-07-01
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-07-16
Who can join
Age: 50 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age older than 50 years.
- Admission to a participating Internal Medicine department within the FADOI Friuli Venezia Giulia network.
- Presence of otherwise unexplained systemic inflammation and/or hematologic abnormalities.
- At least one of the following clinical or laboratory findings:
- unexplained fever;
- elevated C-reactive protein and/or erythrocyte sedimentation rate;
- macrocytic anemia;
- thrombocytopenia or other cytopenias;
- systemic inflammatory manifestations without a clearly identified cause.
- Availability of clinical, laboratory, and imaging data required for assessment according to the study screening pathway.
- Provision of informed consent, where required by the approved study protocol and applicable regulations.
You may not qualify if…
- Systemic inflammation adequately explained by an active infection.
- Systemic inflammation adequately explained by a solid malignancy.
- Clinical or laboratory abnormalities with another clearly established etiology.
- Insufficient clinical or laboratory information to assess eligibility according to the study screening pathway.
- Inability or refusal to provide informed consent, where consent is required.
Full record on ClinicalTrials.gov
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