Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)

Starting soon

Conditions studied: Hypothyroidism

In brief

This hospital-based observational cross-sectional study aims to investigate the morphometric characteristics of internal organs and the morphofunctional status of the musculoskeletal system in adult patients with previously diagnosed hypothyroidism. The study will evaluate ultrasonographic morphometric characteristics of the liver, pancreas, and kidneys, as well as anthropometric and functional characteristics of the musculoskeletal system. Associations between these outcomes and clinical characteristics, anthropometric parameters, physical activity, and laboratory findings will also be assessed. The study is expected to identify accessible clinical, anthropometric, and functional markers associated with morphometric and musculoskeletal changes in patients with hypothyroidism, thereby improving risk assessment and early detection of systemic involvement.

Key facts

Study ID

NCT07707830

Run by

Andijan State Medical Institute

People needed

500

Starts

2026-08-01

Expected to finish

2028-12-31

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-59 years.
• Previously established diagnosis of hypothyroidism.
• Receiving routine outpatient or inpatient care at participating healthcare institutions.
• Ability to undergo ultrasonographic, anthropometric, and functional assessments.
• Provision of written informed consent.

You may not qualify if…

• Pregnancy or lactation.
• History of thyroid malignancy.
• Acute infectious or inflammatory disease at the time of enrollment.
• Severe decompensated cardiovascular, hepatic, or renal disease preventing study procedures.
• Neurological or musculoskeletal disorders that preclude functional testing.
• Refusal or inability to provide informed consent.
• Incomplete clinical or laboratory data.

Where it is running

• Andijan State Medical Institute — Andijan, Uzbekistan

Full record on ClinicalTrials.gov

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