Plasma Exchange in Pediatric Autoimmune Encephalitis
Starting soon · Not applicable
Conditions studied: Autoimmune Encephalitis (AE)
In brief
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis. The study population will be divided into two groups, the first group will perform PLEX on consecutive days and the second one will perform it every other day. Then, A Favorable functional outcome measure defined as modified Rankin Scale (mRS) score ≤ 2. The mRS will be assessed by a blinded assessor at the end of the sessions to determine which method has superior efficacy in treatment of autoimmune encephalitis.
Key facts
- Study ID
- NCT07707739
- Run by
- Menoufia University
- People needed
- 22
- Starts
- 2026-08-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-07-16
Who can join
Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Childern diagnosed as autoimmune encephalitis according to Cellucci et al., 2020; acute/subacute onset (<3 months) of encephalopathy with at least one of: new focal CNS findings, seizures, CSF pleocytosis, MRI suggestive of encephalitis, and supportive antibody testing when available.
- Autoimmune encephalitis cases indicated clinically for PLEX as determined by the treating team (e.g., severe disease, refractory to steroids/IVIG or as part of first-line combination therapy).
You may not qualify if…
- Hemodynamic instability not amenable to plasma exchange.
- Severe coagulopathy uncorrectable prior to PLEX (INR >2 despite correction, platelets <50,000/µL unless corrected).
- Contraindications to central venous access placement.
- Enrollment in another interventional trial that would interfere with the outcomes.
Where it is running
- Menoufia university hospital, Pediatric intensive care unit — Shibīn al Kawm, Menoufia Governorate, Egypt
Full record on ClinicalTrials.gov
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