Heart Rate Variability and Medication Adherence in Resistant Hypertension

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Conditions studied: Resistant Hypertension, Medication Adherence, Autonomic Nervous System

In brief

This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.

Key facts

Study ID

NCT07707583

Run by

Nemocnice AGEL Trinec-Podlesi a.s.

People needed

150

Starts

2026-07-20

Expected to finish

2027-12-31

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-75 years with diagnosed essential hypertension
• Treated with ≥3 antihypertensive drugs of different classes, including ≥1 diuretic (resistant hypertension)
• Sinus rhythm
• Able to give informed consent and understand Czech

You may not qualify if…

• Absence of sinus rhythm: atrial fibrillation/flutter, ventricular arrhythmias, higher-degree AV block, pacemaker/ICD with sustained pacing, sustained SVT, or significant ectopy
• Secondary hypertension
• Pregnancy or breastfeeding
• Cognitive impairment precluding informed consent

Where it is running

• Nemocnice AGEL Třinec-Podlesí a.s. — Třinec, Moravian-Silesian Region, Czechia

Full record on ClinicalTrials.gov

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