A Study of Taste- and Olfactory-Evoked Potentials in Patients With Visual Impairment: Taste, Smell, and Vision

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Conditions studied: Central Visual Impairment, Peripherical Visual Impairment, Macular Retinal Dystrophy, Peripherical Macular Dystrophy

In brief

Visual impairment, whether central or peripheral, may influence the plasticity of other sensory modalities, such as taste and smell. Taste-evoked potentials (TEPs) and smell-evoked potentials (SEPs)-methods for analyzing brain activity in response to taste and smell stimuli-allow for the objective assessment of these interactions. This approach has already demonstrated its value in the study of cognitive disorders. This study aims to demonstrate an enhancement of taste and smell capabilities that could compensate for specific visual impairments, particularly in situations involving food choices.

Key facts

Study ID

NCT07707219

Run by

Centre Hospitalier Universitaire Dijon

People needed

50

Starts

2026-09-01

Expected to finish

2028-09-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult: ≥ 18 years and ≤ 60 years
• Individual who has given oral consent
• Individual who has been fasting (no food, drink, or tobacco) for at least 1 hour prior to PEG and PEO measurement
• No cognitive complaints and normal neurological examination.
• Group of patients with visual impairment:
• A. Central: documented bilateral macular dystrophy (e.g., Stargardt disease, Best disease) with confirmed central scotoma (CV 24.2, 10.2, or 30.2).
• B. Peripheral: documented bilateral peripheral retinal dystrophy with confirmed peripheral involvement (CV 30-2 or 24-2).
• Control group: a person with normal vision and no known ophthalmological abnormalities (normal visual acuity and fundus examination) who is precisely matched by sex and smoking status (former smoker who has quit vs. nonsmoker), and approximately matched by age (± 5 years) to a visually impaired participant included in the study.

You may not qualify if…

• For this group: patients with visual impairments:
• Individuals who are not enrolled in or eligible for a social security program
• Individuals subject to a legal protective measure (guardianship, conservatorship)
• Individuals subject to judicial safeguard measures
• Adults who are legally incapacitated or unable to give informed consent
• Documented COVID-19 infection within the 6 months prior to enrollment
• Active smokers (≥1 cigarette per day) or users of any other inhaled substances (water pipe, cannabis, etc.)
• Participants following a sugar-free diet
• Participants with diabetes, of any type
• Participants taking medication (ongoing during the study) that interferes with taste perception • Pregnant or breastfeeding women
• Individuals with neurodegenerative diseases (Parkinson's, Alzheimer's)
• Individuals with braids, dreadlocks, or any other hairstyle that prevents electrodes from being placed in sufficiently precise locations on the scalp.
• Overweight subjects with a BMI ≥ 35 kg/m²

Where it is running

• Chu Dijon Bourgogne — Dijon, France

Full record on ClinicalTrials.gov

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