Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement

Starting soon · Not applicable

Conditions studied: Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone

In brief

This clinical trial tests how well monitoring the sacral reflexes during surgery (intraoperatively) works to predict the post operative function for patients undergoing removal of the lowest part of the spine (sacrectomy) for pelvic bone cancers or patients undergoing spinal procedures. These surgical procedures can lead to damage to sacral root nerves which can result in impairment to the lower extremities, bowel, bladder, and sexual function. Intraoperative monitoring of sacral reflexes can provide objective, real-time information about pelvic nerve function during surgery. This can aid surgical decision-making and help surgeons better prepare patients to understand the changes that may have occurred to their function as a result of surgery. Intraoperative neuromonitoring may work well to predict postoperative function in patients undergoing sacrectomy for pelvic bone malignancy or patients undergoing spinal procedures.

Key facts

Study ID

NCT07707024

Run by

City of Hope Medical Center

People needed

50

Starts

2027-01-10

Expected to finish

2029-06-10

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented informed consent of the participant and/or legally authorized representative.
• Assent, when appropriate, will be obtained per institutional guidelines
• Age: ≥ 18 years
• Ability to complete study questionnaires
• Willingness to comply with all study procedures, including postoperative patient-reported outcome (PRO) assessments
• Undergoing surgery at City of Hope involving either:
• Complete or partial sacrectomy for primary or metastatic bone tumors, or
• Thoracolumbar intervention in which the sacral roots are not exposed or manipulated (reference cohort)

You may not qualify if…

• Prior sacrectomy or prior surgery resulting in complete sacral nerve transection
• For thoracolumbar cohort patients, prior diagnosis or patient report of bowel or bladder dysfunction
• Cognitive or psychiatric conditions preventing reliable completion of PRO instruments

Where it is running

• City of Hope Medical Center — Duarte, California, United States

Full record on ClinicalTrials.gov

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