A Randomized Controlled Trial Comparing Posterior Nasal Nerve Ablation Procedures for Chronic Rhinitis

Enrolling by invitation · Not applicable

Conditions studied: Chronic Rhinitis, Non-allergic Rhinitis

In brief

The goal of this clinical trial is to learn which procedural intervention most effectively reduces symptoms of chronic rhinitis (non-allergic rhinitis) in adult patients (18 years and older). The main questions it aims to answer are: * Which procedural intervention leads to the greatest reduction in total nasal symptom scores (TNSS)? * Which procedural intervention leads to the greatest improvement in sinonasal quality of life as measured by the SNOT-22? Researchers will compare radiofrequency ablation (RhinAer or Neuromark) and cryotherapy (ClariFix) to see if there are differences in symptom reduction and durability of response across treatments. Participants will: * Be randomly assigned to one of three FDA-cleared posterior nasal nerve ablation procedures (RhinAer, Neuromark, or ClariFix) * Complete validated symptom questionnaires (TNSS and SNOT-22) before and after their procedure * Have their relevant medical records reviewed (demographics, clinical history, prior rhinitis treatments)

Key facts

Study ID

NCT07706595

Run by

University of California, San Diego

People needed

50

Starts

2024-07-18

Expected to finish

2027-08-31

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Diagnosis of chronic rhinitis (non-allergic rhinitis)

You may not qualify if…

• Under 18 years of age

Where it is running

• Perlman Medical Office at UC San Diego — La Jolla, California, United States
• Veterans Affairs San Diego Healthcare System — San Diego, California, United States

Full record on ClinicalTrials.gov

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