Sex-Divergent Effects of Magnesium L-Threonate Supplementation on Sleep Quality, Cognitive Performance, and Neuromuscular Function in Healthy Adults

Completed · Not applicable · Has a placebo group

Conditions studied: Healthy Adults; Cognitive Performance; Sleep Quality; Neuromuscular Function

In brief

This study examined the effects of six weeks of magnesium L-threonate (MgT) supplementation on sleep quality, cognitive performance under experimentally induced mental fatigue, neuromuscular function, and psychophysiological outcomes in healthy adults. Biological sex and weight status were examined as pre-specified moderating variables.

Key facts

Study ID

NCT07706283

Run by

Barry University

People needed

81

Starts

2025-12-01

Expected to finish

2026-03-19

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male or female adults aged 18-45 years
• Free from diagnosed neurological, cardiovascular, metabolic, or psychiatric conditions
• Not currently taking medications or supplements known to influence cognitive or neuromuscular function
• Willing to maintain habitual diet, physical activity, and sleep routines throughout the study period

You may not qualify if…

• Pregnant or breastfeeding
• Diagnosed sleep disorder
• Initiated any new supplement or medication regimen within the past three months
• Failed to meet ≥85% supplementation adherence threshold during the study (post-enrollment exclusion)
• Technical data malfunction resulting in unrecoverable testing data (post-enrollment exclusion)
• Identified as a multivariate outlier (values exceeding ±3 SD from the group mean on primary outcomes; post-enrollment exclusion)

Where it is running

• Barry University — Miami Shores, Florida, United States

Full record on ClinicalTrials.gov

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