Enhancing Rehabilitation in Aging Study (ERAS)

Starting soon · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Adults

In brief

Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity. The hypothesis is pre-treatment with adenosine 2A receptor inhibition (A2AI) enhances AIH effects on motor plasticity in unaffected adults. AIH exposures will be paired with A2AI or placebo, with a 4-week washout. Primary outcome measures include inspiratory and grip strength.

Key facts

Study ID

NCT07704385

Run by

University of Florida

People needed

38

Starts

2026-10-01

Expected to finish

2031-12-31

Last updated by the study team

2026-07-15

Who can join

Age: 40 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 40-79 years Non-smokers Ambulatory in the community Do not require assistance to complete activities of daily living

You may not qualify if…

• Restrictive or obstructive lung conditions Pregnancy Active respiratory infections Use of antibiotics in the last 4 weeks Symptomatic cardiac disease BMI >35 kg/m2 Seizure disorder or progressive neurological condition Uses positive pressure mechanical ventilation when awake and upright, or oxygen assistance at any time

Full record on ClinicalTrials.gov

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