Superoxide Dismutase Skin Spray for the Prevention of Acute Radiation Dermatitis in Head and Neck Cancer

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Radiation-induced Dermatitis

In brief

To evaluate the efficacy and safety of superoxide dismutase skin spray for the reducing the acute radiation dermatitis in patients with head and neck malignancies undergoing radiotherapy.

Key facts

Study ID

NCT07704372

Run by

West China Hospital

People needed

140

Starts

2026-07-15

Expected to finish

2027-04-30

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed malignant tumors of the head and neck without distant metastasis.
• Scheduled to undergo either postoperative adjuvant radiotherapy or definitive radiotherapy, with or without concurrent chemotherapy.
• Age 18-80 years at the time of consent.
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
• Signed informed consent form.
• Adequate cognitive and reading abilities to complete the questionnaire.

You may not qualify if…

• Pre-existing skin disease or open wounds in the irradiation field.
• Have a history of head and neck radiotherapy.
• Autoimmune or connective tissue disorders affecting skin.
• Known allergy to any component of study formulations.
• Any condition that, in the investigator's judgment, would interfere with study participation or outcome assessment.

Where it is running

• Sichuan University West China Hospital — Chengdu, Sichuan, China

Full record on ClinicalTrials.gov

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