Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery
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Conditions studied: Acute Kidney Injury, Subclinical Acute Kidney Injury
In brief
This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels will be measured and normalized to urinary creatinine. Biomarker changes will be compared between patients undergoing surgery in 30° and 45° Trendelenburg positions. The study seeks to determine whether these biomarkers can detect early renal injury before clinically significant changes in serum creatinine occur.
Key facts
- Study ID
- NCT07704242
- Run by
- Medipol University
- People needed
- 50
- Starts
- 2026-08-01
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2026-07-15
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
Where it is running
- Medipol Mega University Hospital — Istanbul, Istanbul, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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