Energy Expenditure and Nutrition After Pancreatic Surgery

Recruiting now

Conditions studied: Whipple Procedures, Pancreatic Cancer, Pancreaticoduodenectomy, Pancreatic Neoplasms

In brief

This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors. Patients undergoing pancreatectomy face major metabolic stress, a high burden of preoperative malnutrition, and frequent exocrine or endocrine insufficiency, yet procedure-specific nutritional guidance is limited. The study measures resting energy expenditure (REE) directly by indirect calorimetry during the early postoperative period and compares it with widely used predictive equations (Harris-Benedict, Schofield) and simplified weight-based targets (25 and 30 kcal/kg) to determine how accurately clinicians can estimate energy needs when calorimetry is unavailable. In the same patients, the study records the route of postoperative nutrition (enteral, parenteral, or combined), energy and protein intake relative to requirements, and diet-related symptoms, and follows postoperative complications, hospital readmission, mortality, and changes in body weight and body mass index through 3-6 months after surgery. By capturing measured energy expenditure and nutritional delivery in one cohort, the study aims to clarify whether adequacy of energy and protein intake, feeding route, or both influence recovery, and to provide primary data for developing individualized nutritional support protocols in this high-risk surgical population.

Key facts

Study ID

NCT07703813

Run by

Evangelismos Hospital

People needed

150

Starts

2017-01-10

Expected to finish

2028-11-10

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Scheduled to undergo total or partial pancreatectomy (including pancreaticoduodenectomy/Whipple procedure or distal pancreatectomy) for a pancreatic tumor
• Able to complete indirect calorimetry measurement by canopy or face mask for the required duration
• Able to provide written informed consent

You may not qualify if…

• Age under 18 years, greater than 75 years
• Pregnancy
• Inability to tolerate the calorimetry canopy or mask for the duration required for a valid measurement
• Unable or unwilling to provide informed consent
• patients already on preoperative enteral nutrition or unable to feed orally preoperatively

Where it is running

• Evaggelismos General Hospital — Athens, Attica, Greece (enrolling)

Full record on ClinicalTrials.gov

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