NASA Exercise Prebreathe Study

Starting soon · Not applicable

Conditions studied: Decompression Sickness

In brief

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Key facts

Study ID

NCT07702539

Run by

Duke University

People needed

30

Starts

2026-07-13

Expected to finish

2027-02-27

Last updated by the study team

2026-07-14

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Non-smoking volunteers aged 30-60 years
• Able to meet VO2 peak requirements (>35 ml/kg/min males, >30 ml/kg/min females)

You may not qualify if…

• Pregnancy
• Lung disease, heart disease, hypertension, or diabetes
• Musculoskeletal pain conditions
• Requirement for regular medications such as analgesics

Full record on ClinicalTrials.gov

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