Oral Nicotine Product Messaging to Communicate Risk of Use for Young Adults

Completed · Not applicable

Conditions studied: Tobacco-Related Carcinoma

In brief

This clinical trial tests the effect of different types of oral nicotine pouch (ONP) messaging to communicate risk of using these products for young adults. Tobacco use remains the leading preventable cause of death due to cancer and other outcomes in the U.S. Tobacco products vary in the health risks they pose to users. Combustible tobacco products such as cigarettes pose higher risks than noncombustible nicotine and tobacco products such as ONPs. Despite the lower harm potential of ONPs for those who use tobacco, there are potential risks to non-users, especially susceptible young adults. Different types of messaging that include information about absolute risk and addiction, risks of ONPs relative to cigarettes and e-cigarettes, ability to use ONPs instead of cigarettes/e-cigarettes (switching), and the potential benefits of doing so and potential benefits of switching to ONPs may be more or less effective in communicating risk for young adults.

Key facts

Study ID

NCT07702435

Run by

Ohio State University Comprehensive Cancer Center

People needed

607

Starts

2025-08-01

Expected to finish

2025-12-29

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• United States (U.S.) young adults aged 18 - 30 years
• Current cigarette smokers. Current smokers are those who smoked 100 lifetime cigarettes and now are smoking every day or some days
• Current e-cigarette users. Current e-cigarette users are those who have ever tried an e-cigarette or other electronic vaping product even once and are now using every day or some days
• Susceptible nonusers of cigarettes or e-cigarettes. Susceptible nonusers are those who have never tried cigarettes/e-cigarettes and respond with any response other than "definitely not" to any of the following items:
• "Have you ever been curious about using cigarettes/e-cigarettes?"
• "Do you think that you will try a(n) cigarette/e-cigarette soon?"
• "If one of your best friends were to offer you a(n) cigarette/e-cigarette, would you use it?"
• "Do you think you will use cigarettes/e-cigarettes in the next year?"

You may not qualify if…

• Participants who do not meet age and tobacco-related criteria, unable to complete study procedures online in English, or do not reside in the U.S. will be excluded

Where it is running

• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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