Functional Evaluation in Patients With Urea Cycle Disorders (UCD) During a Driving Task

Recruiting now

Conditions studied: Urea Cycle Disorder

In brief

This study is being done to understand how the brain works while people with urea cycle disorder (UCD) perform driving tasks that range from easy to difficult and to look at how that compares to traditional tests of thinking and attention.

Key facts

Study ID

NCT07701694

Run by

St. Jude Children's Research Hospital

People needed

60

Starts

2026-07-20

Expected to finish

2032-08-01

Last updated by the study team

2026-07-31

Who can join

Age: 16 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals 16 to 40 years with molecular or biochemical confirmation of a urea cycle disorder.
• Healthy individuals will serve as an age and sex matched comparison group. Active driver's license for at least 6 months
• Read and understand English. as the tasks have not been validated in other languages
• IQ >=70.

You may not qualify if…

• Skin disease that affects the scalp
• Past or present vascular disease
• Head trauma with loss of consciousness in the last year or evidence of cognitive impairment due to and persisting after head trauma
• Motor movement disorder which may cause excessive movement or impede use of the steering wheel and/or pedal
• Premature birth or birth before 32 weeks of gestation
• The participant is taking a stimulant or antidepressant
• Allergy to any component of the device, although expected to be rare
• History of psychosis
• Self-reported motion or cyber sickness
• Self-reported illicit substance use
• Vision disorder

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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