AI-CONECT: A Conversational AI for Early Dementia Prevention in Socially-Isolated Older Adults

Starting soon · Not applicable

Conditions studied: Mild Cognitive Impairment (MCI), Social Isolation

In brief

This randomized controlled trial examines the mechanisms of conversational AI-based interventions for early dementia prevention in socially isolated older adults.

Key facts

Study ID

NCT07701668

Run by

Massachusetts General Hospital

People needed

80

Starts

2026-07-30

Expected to finish

2028-03-31

Last updated by the study team

2026-07-14

Who can join

Age: 75 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 75+
• Clinical diagnosis of MCI, or MMSE ≥ 24 or MoCA ≥ 18 (i.e., early MCI)
• Identified as socially isolated by at least one of the two criteria: (1)score ≤ 12 on the 6-item Lubben Social Network Scale (LSNS-6); (2) engages in conversations lasting 30 minutes or longer, no more than twice per week, per subject self-report
• GDS-15 (15-item Geriatric Depression Scale) at/below 9 (not severely depressed).
• Social self-efficacy mean ≤ 8 (on the 0-10 scale) across the 6-item Social Self-Efficacy Scale at screening, indicating low confidence in social interaction.
• Ability to understand the research consent form.
• Ability to connect a tablet to the Internet.

You may not qualify if…

• Diagnosed with dementia such as AD, ischemic vascular dementia, normal pressure hydrocephalus, or Parkinson's disease.
• Schizophrenia, or other major psychiatric disorder defined by DSM-IV criteria.
• Medications: Frequent use of high doses of analgesics; Use of sedative medications except for those used occasionally for sleep (≤2 per week); Use of unstable dosing of Cholinesterase inhibitors (need to be stable dosing for 2 months).

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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