Hypertonic Saline as a Final Flush and Post-Operative Pain After Single Visit Root Canal Treatment in Mandibular Premolar.
Starting soon · Phase 4
Conditions studied: Symptomatic Irreversible Pulpitis (SIP)
In brief
This randomized controlled trial evaluates whether a final flush with 3% hypertonic saline, compared with 0.9% normal saline, reduces post-operative pain and periapical Substance P (SP) levels after single-visit root canal treatment in mandibular premolars with symptomatic irreversible pulpitis. Forty adult patients will be randomized 1:1. Pain will be measured with the Visual Analogue Scale (VAS) at 6, 12, 24, and 48 hours post-operatively. Periapical fluid SP levels will be measured by ELISA at two intra-operative time points (after working length determination, and after the final flush). The number of ibuprofen 400 mg tablets consumed within 24-48 hours will also be recorded.
Key facts
- Study ID
- NCT07701551
- Run by
- Cairo University
- People needed
- 40
- Starts
- 2026-08-01
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-07-14
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-60 years, any sex
- Systemically healthy
- Mandibular premolar with clinically/radiographically diagnosed symptomatic irreversible pulpitis (prolonged, exaggerated response to cold testing; no periapical radiolucency)
- Able to use the VAS scale and complete follow-up
You may not qualify if…
- Medically compromised patients
- Pregnant or lactating women
- Allergy/hypersensitivity to local anesthetics or NSAIDs
- Analgesics, anti-inflammatories, or antibiotics within 12 hours pre-treatment
- Vertical root fracture, root resorption, or previous RCT
- Radiographic periapical pathology
- Non-restorable teeth
- TMD, bruxism, or traumatic occlusion interfering with pain assessment
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.