A Study of Eloralintide (LY3841136) in Healthy Participants
Starting soon · Phase 1
Conditions studied: Healthy Volunteers
In brief
The main purpose of this study is to learn about safety, tolerability and how well the body processes two different eloralintide solutions. Participation in this study will last about 13 weeks, including screening, inpatient treatment, and follow-up.
Key facts
- Study ID
- NCT07701083
- Run by
- Eli Lilly and Company
- People needed
- 58
- Starts
- 2026-07-01
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-07-14
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Are overtly healthy as determined by medical evaluation
- Have a body mass index (BMI) within the range of 20.0 to 32.0 kilogram per square meter (kg/m2), inclusive
You may not qualify if…
- Have known allergies to related compounds of eloralintide, or any of the components of the formulations
- Have significant previous or current history of comorbidities capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the investigational product; or of interfering with the interpretation of data
- Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have glycated hemoglobin greater than or equal to 6.5% or 48 millimole per mole (mmol/mol)
- Have a history of any malignancy within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years
- Have a history or presence of a gastrointestinal (GI) disorder or previous surgery that impacts gastric emptying for example, gastric bypass surgery or pyloric stenosis
- Have obesity induced by other endocrinologic disorders for example, Cushing syndrome, or diagnosed monogenetic or syndromic forms of obesity for example, Melanocortin 4 Receptor deficiency or Prader Willi syndrome
- Have taken approved or investigational medication for weight loss, including glucagon-like peptide-1 receptor agonists (GLP-1 RAs), within the previous 3 months of study screening
- Intend to use any weight loss medications during study participation
Where it is running
- Fortrea Clinical Research Unit — Daytona Beach, Florida, United States
- Fortrea Clinical Research Unit — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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