Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting.

Starting soon · Not applicable · Has a placebo group

Conditions studied: Coronary Artery Disease, Coronary Artery Bypass Graft (CABG), Surgical Wound Healing

In brief

This randomized, double-blind clinical trial aims to evaluate the impact of photobiomodulation therapy on postoperative outcomes in patients undergoing coronary artery bypass grafting (CABG). The study will compare two techniques for saphenous vein graft harvesting: the conventional technique and the no-touch technique. Participants will be randomly allocated into four groups: conventional harvesting with placebo, conventional harvesting with photobiomodulation, no-touch harvesting with placebo, and no-touch harvesting with photobiomodulation. The primary objective is to evaluate the effects of photobiomodulation on wound healing and postoperative complications related to the saphenous vein harvesting site. Secondary outcomes include clinical outcomes and functional capacity after surgery. The results may contribute to improving postoperative recovery and optimizing surgical strategies in patients undergoing myocardial revascularization.

Key facts

Study ID

NCT07699679

Run by

Federal University of São Paulo

People needed

292

Starts

2026-08-01

Expected to finish

2028-03-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients diagnosed with coronary artery disease scheduled to undergo elective coronary artery bypass grafting (CABG)
• Use of the saphenous vein as a graft for myocardial revascularization
• Ability to understand the study procedures and provide written informed consent

You may not qualify if…

• Emergency coronary artery bypass surgery
• Previous surgery in the lower limb that prevents saphenous vein harvesting
• Active infection at the surgical site or lower limb
• Severe peripheral arterial disease in the lower limbs
• Hemodynamic instability preventing study protocol procedures
• Participation in another interventional clinical trial that may interfere with the outcomes of this study
• Patients unable to perform postoperative functional capacity assessments
• Individuals with highly pigmented skin or sensibility that may alter light absorption and penetration of the photobiomodulation therapy.

Where it is running

• Hospital São Paulo, Federal University of São Paulo — São Paulo, São Paulo, Brazil

Full record on ClinicalTrials.gov

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