Lung Health and the Microbiome Among Adults in Botswana: the Go-hema Cohort

Recruiting now

Conditions studied: Obstructive Pulmonary Disease, Restrictive Pulmonary Disease

In brief

Chronic respiratory diseases like chronic obstructive pulmonary disease (COPD) are responsible for millions of deaths each year, the majority of which occur in low- and middle-income countries (LMICs). LMICs also have high rates of abnormal lung function, including restrictive spirometric pattern (RSP), which can precede the development of chronic respiratory diseases and is associated with all-cause mortality. Additionally, LMICs in sub-Saharan Africa are home to the majority of the world's population of people with HIV (PWH). HIV increases the risk of COPD and COPD associated mortality, but the mechanisms underlying this risk are incompletely understood.

Key facts

Study ID

NCT07699614

Run by

Duke University

People needed

900

Starts

2024-12-01

Expected to finish

2030-12-20

Last updated by the study team

2026-07-13

Who can join

Age: 35 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults 35 years of age or older
• In case at a clinic in Botswana
• Documented HIV status
• Ability to provide informed consent

You may not qualify if…

• Respiratory infection in the prior 4 weeks
• Active pulmonary tuberculosis
• Inability to perform spirometry including eye, abdominal, or
• Thoracic surgery or myocardial infarction in the prior 6 weeks
• Pregnancy

Where it is running

• Local Health Facilities in Gaborone — Gaborone, Botswana (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.