Preoperative Dexamethasone Injection to Improve Local Anesthesia Success in Endodontic Treatment

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Symptomatic Irreversible Pulpitis

In brief

This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) . The findings may help improve pain management strategies during root canal treatment .

Key facts

Study ID

NCT07699315

Run by

Watim Medical & Dental College

People needed

60

Starts

2026-07-01

Expected to finish

2026-12-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with pain VAS >/= 6
• Carious exposed mandibular molar with symptomatic irreversible pulpitis
• Patients between ages 18-60 years
• American Society of Anesthesiologists class I or II medical histories -

You may not qualify if…

• Patients with contraindications to local anesthesia solution or dexamethasone 2.Pregnant or breast-feeding females 4.Tooth having fused/extra roots, full coverage crowns, or poor periodontal status 5. Patients taking drugs which could affect the pain perception

Full record on ClinicalTrials.gov

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