Effect of Controlled Hypotension on GFAP and Cognition in Rhinoplasty

Starting soon

Conditions studied: Nasal Septum Deviation, Rhinoplasty, Induced Hypotension

In brief

This prospective observational study aims to evaluate the neurological safety of controlled hypotension (Mean Arterial Pressure 50-65 mmHg) during elective rhinoplasty. The investigators will assess whether this standard intraoperative hypotensive strategy causes cellular stress by measuring serum Glial Fibrillary Acidic Protein (GFAP) levels and early postoperative cognitive changes using the Montreal Cognitive Assessment (MoCA) test.

Key facts

Study ID

NCT07699133

Run by

Kahramanmaras Sutcu Imam University

People needed

40

Starts

2026-07-10

Expected to finish

2027-03-30

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for elective rhinoplasty or septorhinoplasty under general anesthesia.
• ASA physical status I or II.
• Literate and willing to provide written informed consent.

You may not qualify if…

• History of neurological (e.g., cerebrovascular event, epilepsy) or psychiatric diseases.
• Total septal reconstruction requiring costal (rib) cartilage grafts.
• Expected surgical duration exceeding 3 hours.
• Preoperative severe cognitive impairment.
• Pregnancy or lactation.

Full record on ClinicalTrials.gov

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