Endovascular Treatment of Chronic Intracranial Artery Occlusion

Starting soon · Not applicable

Conditions studied: Chronic Intracranial Artery Occlusion

In brief

Comparison of the efficacy and safety of endovascular treatment versus medical treatment in patients with chronic intracranial artery occlusion.

Key facts

Study ID

NCT07699003

Run by

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

People needed

382

Starts

2026-08-01

Expected to finish

2030-08-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Occlusion of the unilateral middle cerebral artery, basilar artery, intracranial internal carotid artery, or vertebral artery, as confirmed by computed tomography angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA)
• Modified Rankin Scale (mRS) score of 0-2
• Presence of symptoms related to the occluded vessel, as determined by the physician, with the most recent symptom onset occurring more than 4 weeks and within 6 months prior to enrolment
• The subject or their legally authorised representative has provided written informed consent for the study

You may not qualify if…

• Evidence of hemorrhage on CT or MRI
• Large hemispheric infarction involving >50% of the middle cerebral artery territory on CT or MRI
• Severe pre-stroke disability (modified Rankin Scale score ≥2) or life expectancy <12 months
• Major comorbidities that may interfere with outcome assessment and follow-up (e.g., severe heart failure, renal failure, etc.)
• Uncontrolled seizure at the time of stroke onset
• Baseline platelet count <50,000/μL
• Severe, persistent hypertension that remains uncontrolled despite active management (systolic blood pressure >220 mmHg or diastolic blood pressure >120 mmHg)
• Known inherited or acquired bleeding diathesis, coagulation factor deficiency, or recent oral anticoagulant therapy with an international normalized ratio (INR) >3
• Suspected septic emboli or suspected bacterial endocarditis
• Known allergy to iodine, heparin, or anaesthetics, or other definite contraindications to endovascular procedures
• Pregnant women
• Other severe, progressive, or terminal diseases (as judged by the investigator), or life expectancy <24 months
• Prior attempted endovascular recanalization therapy before randomization
• Current participation in other studies involving investigational drugs or devices
• Evidence of intracranial tumour on CT or MRI (except meningioma)
• Excessive tortuosity of cervical vessels on CTA/MRA that may preclude endovascular therapy

Full record on ClinicalTrials.gov

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