Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death

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Conditions studied: Organ Donation After Circulatory Death

In brief

The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.

Key facts

Study ID

NCT07698262

Run by

University of British Columbia

People needed

102

Starts

2027-01-01

Expected to finish

2030-12-01

Last updated by the study team

2026-07-13

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 19;
• Eligible for DCD

You may not qualify if…

• Exclusion criteria will consist of :
• concurrent vasopressor doses of norepinephrine >0.05 mcg/kg/min (or dose equivalent)
• PaO2/FiO2 ratio <150 mmHg
• complete high cervical spinal cord injury (C5 and above)
• cardiac support devices (e.g., ECMO, balloon pump, ventricular assist device)
• pacemaker in situ
• tracheostomy

Where it is running

• Cumming School of Medicine — Calgary, Alberta, Canada
• UBC/East Kootenay Regional Hospital — Cranbrook, British Columbia, Canada
• Kelowna General Hospital — Kelowna, British Columbia, Canada
• Royal Columbian Hospital — New Westminster, British Columbia, Canada
• Surrey Memorial Hospital — Surrey, British Columbia, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• University of Manitoba Health Sciences Center — Winnipeg, Manitoba, Canada
• University Hospital - London Health Sciences Centre — London, Ontario, Canada
• Lakeridge Health — Oshawa, Ontario, Canada
• Children's Hospital of Eastern Ontario (CHEO) — Ottawa, Ontario, Canada
• St Paul hospital — Vancouver, Canada

Full record on ClinicalTrials.gov

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