Temporal Interference Noninvasive Deep Brain Stimulation for Idiopathic Parkinson's Disease and Parkinsonian Syndromes: Effects and Target Exploration

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Parkinson's Disease, Parkinsonian Syndromes

In brief

This study aims to explore the therapeutic effects of noninvasive deep brain electrical stimulation using temporal interference principles (Temporal Interference Stimulation, TIS) on both motor and non-motor symptoms in patients with idiopathic Parkinson's disease and Parkinsonian syndromes, and to investigate strategies for optimal stimulation target selection. A prospective, single-center, double-blind, randomized, crossover design will be implemented. Participants will be recruited from outpatient and inpatient departments of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. The primary hypothesis is that TIS will significantly improve motor symptoms in patients with Parkinson's disease and Parkinsonian syndromes. The primary outcome measure will be the change in the MDS-UPDRS Part III score from baseline to post-stimulation. This study is expected to provide direct evidence supporting the clinical application and target selection strategies of noninvasive deep brain stimulation for the treatment of Parkinson's disease and Parkinsonian syndromes.

Key facts

Study ID

NCT07698236

Run by

Ruijin Hospital

People needed

100

Starts

2026-07-03

Expected to finish

2026-09-30

Last updated by the study team

2026-07-13

Who can join

Age: 40 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 40 to 80 years, diagnosed with idiopathic Parkinson's disease or Parkinsonian syndromes according to the Movement Disorder Society (MDS) diagnostic criteria.
• Receiving stable doses of levodopa or other dopaminergic medications for at least 4 weeks prior to enrollment, with a documented response to levodopa; medication regimen must remain unchanged during the study.
• Hoehn and Yahr (H\&Y) stage ≤ 3 in the "ON" medication state.
• Normal cognitive function, defined as a Mini-Mental State Examination (MMSE) score ≥ 24.
• Able to maintain and cooperate with Parkinson's disease symptom diaries.
• Signed written informed consent.

You may not qualify if…

• Presence of other neurological or psychiatric disorders that may interfere with study participation or outcomes.
• Previous treatment with deep brain stimulation (DBS) or other invasive brain stimulation therapies.
• Orthopedic or other medical conditions that could affect gait or balance.
• Contraindications to MRI, such as claustrophobia or other factors making MRI unsuitable.
• History of taking antipsychotic, antidepressant, or other medications that may affect dopamine levels.
• Contraindications to electrical stimulation, such as implanted cardiac pacemakers or a history of epilepsy.
• History of electroconvulsive therapy (ECT).
• Severe comorbidities, including cardiovascular disease, respiratory disease, or hepatic/renal dysfunction.

Where it is running

• Shanghai Jiao Tong University School of Medicine Affiliated Ruijin Hospital — Shanghai, China

Full record on ClinicalTrials.gov

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