Exercise Intervention and Immunodeficiency
Recruiting now · Not applicable
Conditions studied: Primary Antibody Deficiency Disorders
In brief
The purpose of this study is to assess if a 12-week exercise program is safe, practical, and acceptable for adults with primary antibody deficiencies. It also looks at whether the program can improve the quality of life and help the immune system work better.
Key facts
- Study ID
- NCT07698197
- Run by
- Yale University
- People needed
- 20
- Starts
- 2026-07-17
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-23
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed with one of the following primary antibody deficiencies: IgG subclass deficiency, selective IgA deficiency, selective IgM deficiency, or specific antibody deficiency
- Receiving care in the Section of Rheumatology, Allergy \& Immunology
- Able and willing to participate in a moderate-intensity exercise program. Patients will be screened using the American College of Sports Medicine (ACSM) Pre- participation Screening Guidelines. This algorithm assesses patients for cardiovascular, renal, and metabolic disease. Those patients determined to not require further medical clearance to participate in exercise will be included.
You may not qualify if…
- Receipt of immunoglobulin (Ig) replacement therapy
- Use of immunosuppressive or immunomodulatory medications (e.g., chronic systemic corticosteroids, B-cell-depleting therapies)
- Medical contraindications to moderate-intensity exercise as determined by clinical assessment using the previously discussed ACSM Pre-participation Screening Guidelines.
- Other risk factors/medical conditions that would limit safe participation in exercise as determined by clinical assessment, including active rheumatologic conditions including active rheumatoid arthritis.
Where it is running
- Bridgeport Hospital — Milford, Connecticut, United States (enrolling)
- Yale New Haven Health — North Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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