Venous Thromboembolism (VTE) Prophylaxis With REGN7508 and REGN9933 in Adult and Adolescent Participants With a Peripherally Inserted Central Catheter (PICC)

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Venous Thromboembolism (VTE)

In brief

This study is researching 2 different experimental drugs called REGN7508 and REGN9933 (called "study drugs"). The study is focused on people who have a tube placed in a vein to receive treatment (called Peripherally Inserted Central Catheter \[PICC\]). Patients with PICCs have a higher risk of getting blood clots which can block the veins (this is called Venous Thromboembolism \[VTE\]) and lead to serious health problems or be life threatening. The aim of the study is to see how well REGN7508 and REGN9933 prevent blood clots compared to placebo after PICC placement and to see if these medications cause certain types of bleeding. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drugs (which could make the drugs less effective or could lead to side effects) * If the study drugs affect the ability of the blood to clot normally

Key facts

Study ID

NCT07697599

Run by

Regeneron Pharmaceuticals

People needed

1908

Starts

2026-08-20

Expected to finish

2029-09-21

Last updated by the study team

2026-07-13

Who can join

Age: 15 and older. Sex: any. Healthy volunteers: not accepted.

Full record on ClinicalTrials.gov

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