Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock

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Conditions studied: Septic Shock and Use of Vasopressin

In brief

In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized. Available data suggest variable responses, which may depend on the hemodynamic phenotype at the time of treatment initiation. In particular, the effects of vasopressin may differ according to the presence of preload dependency, baseline cardiac output, impaired systolic function, or baseline diastolic arterial pressure, reflecting the degree of vasoplegia. In this context, the VASO-PHENO study aims to provide a detailed and dynamic description of the early hemodynamic and clinical effects of vasopressin initiation in septic shock. To date, no clinical study has systematically and dynamically evaluated the effects of vasopressin on central and peripheral hemodynamic parameters according to the hemodynamic profile at the time of its initiation. Describing these effects appears essential to better understand the variability in clinical responses and to contribute to a more rational and personalized approach to vasopressor escalation in septic shock.

Key facts

Study ID

NCT07697144

Run by

Assistance Publique - Hôpitaux de Paris

People needed

200

Starts

2026-08-01

Expected to finish

2029-09-01

Last updated by the study team

2026-07-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years;
• Hospitalized in an intensive care unit;
• Presenting with septic shock according to Sepsis-3 criteria;
• For whom the treating clinician wishes to initiate vasopressin as second-line therapy as part of routine care;
• Undergoing hemodynamic monitoring with a PiCCO2 device (Pulsion Medical Systems, Getinge, Feldkirchen, Germany) or pulmonary artery catheterization as part of routine care.

You may not qualify if…

• Patient already receiving vasopressin;
• Pregnancy;
• Patient under legal protection;
• Patient unwilling to participate in the study.

Where it is running

• CHU d'Angers — Angers, France
• CH de Dieppe — Dieppe, France
• Hôpital Bicêtre — Le Kremlin-Bicêtre, France
• GHE, Hôpital Louis Pradel, HCL — Lyon, France
• GHS - Hôpital Lyon Sud, HCL — Lyon, France
• Hôpital Nord, AP-HM — Marseille, France
• CHU Rennes - Site Pontchaillou — Rennes, France
• Hôpital Hautepierre, Hôpitaux Universitaires de Strasbourg — Strasbourg, France

Full record on ClinicalTrials.gov

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