Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Starting soon · Not applicable
Conditions studied: Surgical Site Infection (SSI)
In brief
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions. Systemic antibiotic prophylaxis alone often fails to achieve adequate local tissue concentrations at the incision site due to impaired perfusion, contributing to persistently high SSI rates in this population. This trial evaluates subcutaneous infiltration of levofloxacin, a broad-spectrum fluoroquinolone with favorable tissue penetration, administered along the wound edges immediately prior to skin closure, as an adjunct to standard surgical and antibiotic management. This study is investigator-initiated and will be conducted as a single-center trial within the Department of Surgery, Sylhet MAG Osmani Medical College Hospital.
Key facts
- Study ID
- NCT07696819
- Run by
- Sylhet M.A.G.Osmani Medical College
- People needed
- 90
- Starts
- 2026-08-01
- Expected to finish
- 2026-10-31
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 18 years and above
- Patients undergoing emergency laparotomy for contaminated surgical pathology
- Patients undergoing emergency laparotomy for dirty/infected surgical pathology
You may not qualify if…
- Patients with known hypersensitivity to levofloxacin or other fluoroquinolones
- Pregnant women or lactating mothers
- Patients with pre-existing severe renal impairment
- Patients with pre-existing skin infection at the incision site
- Patients requiring re-laparotomy within 48 hours
Where it is running
- Sylhet MAG Osmani Medical College — Sylhet, Bangladesh
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.