ULTIMATE Study (Carotid Ultrasound Vs CT Coronary Calcium Scoring to Reclassify Symptomatic Patients With Chronic Coronary Syndrome)

Recruiting now · Not applicable

Conditions studied: Chronic Coronary Syndrome, Obstructive Coronary Artery Disease

In brief

* Chest pain is one of the most common symptoms of heart disease. This could be due to narrowing in heart's blood vessels, which needs to be investigated. * Currently, people with a low risk of narrowing of heart vessels usually have a CT scan of the heart first. This scan is good at identifying those who do not have significant narrowing. However, the scan has some drawbacks, such as exposure to a small amount of radiation. * We are exploring if ultrasound of the neck vessels might give us similar kind of information as the CT scan. * You will be asked to attend the hospital for one visit to have an ultrasound scan of your neck. * The findings of your neck vessels will be compared with the CT scan of your heart vessels to see if there is a similarity.

Key facts

Study ID

NCT07696533

Run by

London North West Healthcare NHS Trust

People needed

225

Starts

2026-07-03

Expected to finish

2032-11-30

Last updated by the study team

2026-07-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years old
• Symptomatic patients with suspected CCS, judged by the clinician to require CTCA with CAC scoring, for the diagnosis of CAD
• Have a RF-CL 5-15%, as calculated using ESC guidelines
• Able to give informed consent to participate in the study and its follow up

You may not qualify if…

• Age <18 years old
• Diagnosed ACS requiring hospitalization or urgent or emergent testing
• Known CAD with prior MI, PCI, CABG or any angiographic evidence of CAD (≥50% lesion in a major epicardial vessel)
• History of previous stroke or known peripheral vascular disease
• Known significant cardiac congenital abnormalities
• Pregnancy
• Life expectancy < 1 years
• Unable to provide written informed consent

Where it is running

• Northwick Park Hospital — Harrow, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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